RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
miR-486-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay; Immunoblot etc.
Target
Smad2
Pathway
NA
PubMed ID
Title
The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis
Year
2015
Function
"The dysregulation of five miRNAs, including miR-21, miR-455, miR-151-3p, miR-486-5p and miR-3107, were confirmed by qRT-PCRs in silica-induced mouse model of pulmonary fibrosis and were also confirmed in a bleomycin (BLM)-induced mouse lung fibrosis. Notably, miR-486-5p levels were decreased in the serum samples of patients with silicosis, as well as in the lung tissues of patients with silicosis and idiopathic pulmonary fibrosis (IPF). SMAD2 was identified to be one of target genes of miR-486-5p. MiR-486-5p expression significantly decreased both the distribution and severity of lung lesions compared with the silica group (P < 0.01)."